The Ideal Biomaterial

Silicon nitride plays an active role in promoting faster bone fusion.

What is Silicon Nitride?

Silicon nitride was first prepared in 1857 and was little more than a chemical curiosity for nearly a century. However, things changed in the late 1940s when the compound began to be used across multiple industries, ultimately becoming a key component in electronics, turbo machinery, bearings, and even orbital satellites.

Our founders discovered that silicon nitride is stronger than bone (and 20x stronger than PEEK), biologically kind (accepted by the human body), and bone-like in imaging (artifact-free). This discovery has allowed us to develop our own proprietary composition of silicon nitride, which provides physicians with a strong material that is highly reliable, wear-resistant, and has the unique ability to bond to bone.

Today, silicon nitride is leading a revolution in interbody fusion

At Amedica, we are the only company with the ability to manufacture interbody fusion devices from medical-grade silicon nitride.

Valeo® C Interbody Device

Outperforming PEEK and titanium

Silicon nitride has the ability to achieve superior new bone growth. Along with proven antibacterial properties and enhanced imaging attributes, the benefits are extensive.

Sharing Our Expertise

Let our leading R&D and manufacturing teams convert your existing medical devices into silicon nitride. Our unique biomaterial is ideal for a wide variety of medical applications including spine, dental, hip, knee, extremities, etc.

Our OEM Strategy

Silicon nitride possesses qualities that promote clinical success

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Key Benefits of Silicon Nitride

Enhanced osteopromotion

The surface chemistry and nanostructure topography of silicon nitride provide an optimal environment for stimulation of osteoprogenitor cells to differentiate into osteoblasts.

Greater new bone formation Increased protein adsorption

Increased protein adsorption

Silicon nitride demonstrates significantly greater protein adsorption in comparison to PEEK and titanium. Proteins such as fibronectin, laminin, and vitronectin are key to the osteogenic process.1

Enhanced osteopromotion Greater new bone formation

Greater new bone formation

Silicon nitride implants demonstrate greater new bone formation at 3, 7, 14, and 90 days compared to PEEK and titanium. Regenerated bone associated with silicon nitride implants is 2-3 times greater than PEEK and titanium implants three months after surgery.1

Increased protein adsorption Enhanced osteopromotion

Bacteriostatic properties

Silicon nitride demonstrates significantly lower biofilm formation at 4, 24, 48 and 72 hours as compared to PEEK and titanium. In related rodent studies, no live bacteria were observed around previously inoculated silicon nitride implant at 3 months, whereas comparable PEEK and titanium implants showed persistent, live bacteria 3 months after surgery. Silicon nitride demonstrates this behavior even in the absence of antibiotics.2

Compatible with all imaging modalities

Silicon nitride implants are radiolucent with clearly visible boundaries, and produce no artifacts or scattering under CT and no distortion under MRI. This enables an exact view of the implant for precise intraoperative placement and postoperative fusion assessment.

1.  Gorth DJ, Puckett S, Ercan B, Webster TJ, Rahaman M, Bal BS. Decreased bacteria activity on Si3N4 surfaces compared with PEEK or titanium. Int J Nanomedicine. 2012;7:4829-4840.

2. Webster TJ, Patel AA, Rahaman MN, Sonny Bal B. Anti-infective and osteointegration properties of silicon nitride, poly(ether ether ketone), and titanium implants [published online ahead of print July 31, 2012]. Acta Biomater.

How Silicon Nitride Compares

Our silicon nitride features a unique nanosurface texture that inspires and promotes bone growth, making it the ideal biomaterial on the market. This innovative material is addressing key clinical needs in a way that titanium or PEEK simply cannot.

Biomaterial Comparison Overview

Antibacterial Properties of Silicon Nitride

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PEEK Titanium Silicon Nitride
Increased bone formation
Artifact-free imaging
Antibacterial properties
Hydrophilic
Increased protein adsorption
Mechanical Strength

*Artifact produced by tantalum markers.

Unrivaled In-House Manufacturing Technique

Our 30,000 sq. ft. ISO 13485 certified manufacturing facility in Salt Lake City, UT is the only FDA and CE cleared silicon nitride medical device manufacturing facility in the world. We have the ability to manufacture intricate designs and shapes that are rigorously tested for quality control.

Our vertically integrated facility allows for rapid prototyping, scientific testing, and product development.

From Powder to Parts

Powder
Press
Mill
Furnace
Implants